concept
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concept:cancer-as-shrinking-of-the-selfCancer as shrinking of the Self
Cancer is interpreted as cells reverting to unicellular selfishness due to loss of gap junctional coupling, shrinking their cognitive boundary.
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Concepts (1)
concept
- Gap Junctionsassociated_withCellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.
Findings (1)
finding
- Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.
- The model that cancer results from cells shrinking their computational boundaries (closing gap junctions) and reverting to unicellular goals.
- Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
- Levin proposes cancer cells become isolated from physiological signals that bind them into organ-level collectives, reverting to unicellular-scale goals, shrinking their computational self.
- Uses the cognitive light cone concept to offer a new framing of cancer as a collective intelligence defection
- Mechanisms by which smaller competent subunits bind into a higher-level Self with larger goals; key example via gap junction connections.
- Cancer is a breakdown of the multiscale binding, leading cells to revert to unicellular goals.hypothesis0.768Gap junction closure makes cells selfish, shrink their cognitive boundary; restoring Vmem can normalize.