finding

active

finding:co-expression-of-a-hyperpolarizing-ion-channel-prevents-tumorigenesis-by-oncogene-p53-in-xenopus-tadpoles

Co-expression of a hyperpolarizing ion channel prevents tumorigenesis by oncogene p53 in Xenopus tadpoles

Bioelectric state modulation can override strong oncogenic mutations, preventing cancer and restoring normal development.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

Neighborhood — ranked by edge-count

Claims (1)

claim

Cancer can be seen as a breakdown of the binding process that scales Selves, with cells reverting to unicellular goals.
supports
Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.

Communities (3)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
members_of
Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric control of cancer and morphogenesis
members_of
Using ion channel manipulation and bioelectric state to suppress tumorigenesis and override oncogenic pathways, pioneered by Michael Levin's group.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Optogenetic hyperpolarization suppresses human oncogenesfinding0.810
Finding that constitutive or optogenetic hyperpolarization can prevent human oncogenes from inducing tumors, supporting bioelectric control of cancer fate.
Artificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.finding0.809
Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.748
Shows that restoring bioelectric cohesion can override single-cell goals.
Misexpression of a single ion channel induces complete ectopic eye formation in gut endoderm of vertebrates.finding0.747
Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.
Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.741
Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
Brief chloride ion channel activator drug exposure converts normal melanocytes to melanoma-like phenotype in an all-or-none population-level fashion (Blackiston et al. 2011, Lobikin et al. 2015)finding0.738
Reveals that melanocytes across the whole animal make a coordinated, stochastic decision to convert or remain normal.
Disruptions in cells' ability to join into a cohesive information-processing network via oncogenes and other factors correlate with cancer developmentfinding0.729
Empirical support for the cancer-as-cognitive-defect / cognitive light cone shrinkage hypothesis
Cancer can be normalized by reconnecting cells to the electrical network that harnesses them toward adaptive tissue homeostasis.claim0.726
Proposes a non-toxic cancer treatment strategy.