Optogenetic hyperpolarization suppresses human oncogenes

Finding that constitutive or optogenetic hyperpolarization can prevent human oncogenes from inducing tumors, supporting bioelectric control of cancer fate.

Source paper

extracted_from

The computational boundary of a 'self': developmental bioelectricity drives multicellularity and scale-free cognition

(2019) · Levin M

Neighborhood — ranked by edge-count

Claims (1)

claim

Cancer as loss of organizational self-boundary
supports
Levin proposes cancer cells become isolated from physiological signals that bind them into organ-level collectives, reverting to unicellular-scale goals, shrinking their computational self.

Communities (3)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
members_of
Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric control of cancer and morphogenesis
members_of
Using ion channel manipulation and bioelectric state to suppress tumorigenesis and override oncogenic pathways, pioneered by Michael Levin's group.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Co-expression of a hyperpolarizing ion channel prevents tumorigenesis by oncogene p53 in Xenopus tadpolesfinding0.810
Bioelectric state modulation can override strong oncogenic mutations, preventing cancer and restoring normal development.
Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.777
Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.769
Shows that restoring bioelectric cohesion can override single-cell goals.
Artificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.finding0.754
Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Bioelectric state manipulation induces metastatic melanoma or suppresses tumorigenesis in wild-type genetic backgroundfinding0.740
Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.
Optogeneticsmethod0.737
Light-gated ion channels used to control bioelectric states and dissect cellular computation.
Cancer Suppression via Bioelectric Network Regulationfinding0.724
Brief chloride ion channel activator drug exposure converts normal melanocytes to melanoma-like phenotype in an all-or-none population-level fashion (Blackiston et al. 2011, Lobikin et al. 2015)finding0.723
Reveals that melanocytes across the whole animal make a coordinated, stochastic decision to convert or remain normal.