V-ATPase proton pump can be functionally replaced by a yeast proton pump with no sequence homology to restore bioelectric state and tail regeneration.

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• V-ATPaseconcept0.748
  Proton pump involved in establishing bioelectric gradients for craniofacial development and left-right patterning.
• H+ pump activation induces full tadpole tail regenerationfinding0.741
  A transient proton pump activation triggers an entire regenerative cascade, demonstrating top-down control of morphogenesis.
• Bioelectric state can reprogram organism morphology and behavior independently of DNA.hypothesis0.740
  Xenopus evolution experiment showing shape and tissue distribution alone drive morphological change.
• Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.hypothesis0.733
  Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
• Manipulating bioelectric states can reprogram target morphology without changing genetics.hypothesis0.719
  Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
• Waves of ATP mediate morphogenetic information sharing and teratogen resistance among groups of embryos.finding0.703
  Tung et al. 2024 finding on cross-embryo morphogenetic assistance (CEMA).
• The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.701
  Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
• Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.finding0.699
  Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.