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finding:planarians-maintain-high-regenerative-fidelity-despite-genetic-heterogeneity-and-chromosomal-variation

Planarians maintain high regenerative fidelity despite genetic heterogeneity and chromosomal variation

Source paper

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Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms

(2023) · Clawson, Wesley P. · Levin, Michael

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Hypotheses (1)

hypothesis

Life exploits multi-scale competency architecture enabling adaptation to novel circumstances much faster than evolution alone.
supports
Authors hypothesize that plasticity observed in individual lifetimes suggests architecture providing greater efficiency than blind evolutionary search.

Communities (3)

community

Bioelectric memory & morphogenetic identity
members_of
Gap junctions and bioelectric signals encode body-plan and memory patterns across radical biological transformation.
Bioelectric control of planarian morphogenesis
members_of
Transient bioelectric manipulation persistently alters head number and patterning despite wild-type genetics in planaria.
Bioelectric code and morphological memory in planarians
members_of
Studies of how ion channel bioelectric patterns encode anatomical information independent of genetics, enabling regeneration fidelity and behavioral memory preservation across complete body regeneration.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Planarian fragments regenerate with near 100% fidelity of anatomical structurefinding0.855
Planarians cut into pieces regenerate precisely what is missing and re-scale tissue to form complete worms.
Planaria reproduce by fissioning without a cellular population bottleneck and accumulate somatic diversity, yet maintain holistic morphology and behaviour (Lobo et al. 2012)finding0.823
Finding showing genetic heterogeneity is not necessary for organismic individuality
Fragments of 2-headed planarians continue regenerating as 2-headed indefinitely despite normal genomefinding0.816
Shows the bioelectric pattern memory is stably heritable across cutting/regeneration cycles absent genetic change.
Planaria have fully committed to a strategy that overrides genetic details with large-scale pattern completion.claim0.811
Interpretive claim explaining planarian robustness as top-down morphogenetic intelligence.
Planarian flatworms are extremely resistant to transgenesis, aging, cancer, and injury despite incredibly noisy genome.finding0.806
Levin et al. 2019 finding on planarian robustness.
Modification of cell-cell communication during planarian regeneration causes genetically-normal fragments to produce heads appropriate to other species (Emmons-Bell et al. 2015, Sullivan et al. 2016)finding0.802
Shows that morphological attractors can be switched via physiological cues, revealing the navigation of morphospace by collectives.
Planarians derived from tail fragments of trained worms retain original information after brain regenerationfinding0.799
Behavioral memories in planaria persist through complete brain regeneration, indicating movement of memory across tissues.
Planaria maintain memories and re-imprint them from tail fragments onto newly regenerating brains.finding0.794
Example of memory dynamics during extreme regeneration.

Cross-corpus bridges (2)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

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Why do animals with highest morphogenetic plasticity and regenerative capacity (e.g., planaria) show greatest cancer resistance despite having high proportions of stem cells?questions/why-do-animals-with-highest-morphogenetic-plasticity-and.md0.800
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How can systems with messy, polyploid genomes maintain the most robust morphological control?questions/how-can-systems-with-messy-polyploid-genomes-maintain.md0.781