finding
active
finding:cells-hetero-grafted-from-tissue-in-one-phase-of-the-segmentation-clock-into-a-different-phase-synchronize-to-the-host-phase-horikawa-et-al-2006Cells hetero-grafted from tissue in one phase of the segmentation clock into a different phase synchronize to the host phase (Horikawa et al. 2006)
Demonstrates that the clock phase is collectively determined; individual cells entrain to the local collective rhythm.
Source paper
extracted_from(2024) · Patrick McMillen · Michael Levin
Neighborhood — ranked by edge-count
Claims (1)
claim
- Argues that stochastic outcomes in regeneration are still collective decisions, not cellular chaos.
Communities (2)
community
- Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
- Cellular bioelectric patterns encode organ identity and developmental decisions at population level, demonstrated through drug/ion channel interventions that toggle phenotypes in all-or-none fashion (Levin group, 2009-2017).
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Robust re-emergence of coordinated oscillations indicates intrinsic intelligence of the segmenting tissue.
- Highlights the non-genetic control of large-scale anatomy.
- Shows that the segmentation goal can be reached via alternative developmental pathways, fitting James' definition of intelligence.
- Collectivity is necessary for the oscillatory behavior of the segmentation clock; individual cells lack the competence.
- Ectopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.
- Keratocytes migrate to the cathode, but keratocyte fragments migrate to the anode (Sun et al. 2013)finding0.738Shows that collective behavior of an intact cell differs fundamentally from the behavior of its parts.
- Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
- Collectives have increased positional memory and resist environmental induction, demonstrating expanded perceptual field in time dimension.