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community:leiden_hybrid_concepts-run4-c2-c5Bioelectric state as morphogenetic collective decision
Cellular bioelectric patterns encode organ identity and developmental decisions at population level, demonstrated through drug/ion channel interventions that toggle phenotypes in all-or-none fashion (Levin group, 2009-2017).
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The papers/notes whose extracted claims & findings make up this cluster.
- Collective intelligence: A unifying concept for integrating biology across scales and substrates7 members
- alexander-and-levin.md1 member
Bridges (3)
Other communities that share members with this one — cross-cutting threads or papers that sit at the seam between two themes.
Findings (6)
- A computational model of melanocyte regulatory pathway revealed state-space decision points explaining all-or-none conversion (Lobikin et al. 2015)Mathematical modeling showed how cells navigate biochemical state space and face collective decision points.
- Brief chloride ion channel activator drug exposure converts normal melanocytes to melanoma-like phenotype in an all-or-none population-level fashion (Blackiston et al. 2011, Lobikin et al. 2015)Reveals that melanocytes across the whole animal make a coordinated, stochastic decision to convert or remain normal.
- Cells hetero-grafted from tissue in one phase of the segmentation clock into a different phase synchronize to the host phase (Horikawa et al. 2006)Demonstrates that the clock phase is collectively determined; individual cells entrain to the local collective rhythm.
- Down-regulation of VANGL signaling caused speckled left-right identity, breaking cellular concordance of laterality (Zhang and Levin 2009)One of the only known perturbations that dissociates the collective left-right decision, producing a mix of identities within a single domain.
- Melanoma conversion is all-or-none at animal level despite population variationIn tadpoles with disrupted bioelectric signaling: different reagents produce 0-100% conversion rates in populations, but individual animals are entirely converted or entirely normal—collective decision-making phenomenon.
- Model-predicted intervention (two drugs and a dominant negative construct) broke concordance among melanocytes, producing first partially-pigmented animals (Lobo et al. 2017)Demonstrates that breaking collective decision-making can be achieved, separating the decision from its coordination across cells.
Claims (2)
- The randomization of bioelectric state and downstream morphogen gradients is interpreted with respect to anterior-posterior organ identity by collectives, not by individual cells.Argues that stochastic outcomes in regeneration are still collective decisions, not cellular chaos.
- Turing's morphogenesis dynamics, D'Arcy Thompson's physical constraints, and Waddington's epigenetic landscape all describe the same phenomenon in different substrates as Alexander and Levin.