finding

active

finding:down-regulation-of-vangl-signaling-caused-speckled-left-right-identity-breaking-cellular-concordance-of-laterality-zhang-and-levin-2009

Down-regulation of VANGL signaling caused speckled left-right identity, breaking cellular concordance of laterality (Zhang and Levin 2009)

One of the only known perturbations that dissociates the collective left-right decision, producing a mix of identities within a single domain.

Source paper

extracted_from

Collective intelligence: A unifying concept for integrating biology across scales and substrates

(2024) · Patrick McMillen · Michael Levin

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Claims (1)

claim

The randomization of bioelectric state and downstream morphogen gradients is interpreted with respect to anterior-posterior organ identity by collectives, not by individual cells.
supports
Argues that stochastic outcomes in regeneration are still collective decisions, not cellular chaos.

Communities (2)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric state as morphogenetic collective decision
members_of
Cellular bioelectric patterns encode organ identity and developmental decisions at population level, demonstrated through drug/ion channel interventions that toggle phenotypes in all-or-none fashion (Levin group, 2009-2017).

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.725
Highlights the non-genetic control of large-scale anatomy.
Misexpression of a single ion channel induces complete ectopic eye formation in gut endoderm of vertebrates.finding0.723
Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.
A computational model of melanocyte regulatory pathway revealed state-space decision points explaining all-or-none conversion (Lobikin et al. 2015)finding0.720
Mathematical modeling showed how cells navigate biochemical state space and face collective decision points.
Turing's morphogenesis dynamics, D'Arcy Thompson's physical constraints, and Waddington's epigenetic landscape all describe the same phenomenon in different substrates as Alexander and Levin.claim0.720
The formation of centers is guided by generic patterns which play the role of genes.claim0.719
Analogy to biology, placing pattern languages as the genetic code for living built environments.
The deep symmetry between problem-solving in anatomical, physiological, transcriptional, and 3D spaces drives specific hypotheses.claim0.717
Evolution pivoted the same problem-solving strategies across different domains.
The remarkable ability of neurons to unify toward a centralized self is an evolutionary pivot of far earlier cell communication strategies that first solved problems in navigating anatomical morphospace.hypothesis0.716
Proposes an evolutionary trajectory linking morphogenesis to neural cognition.
Resting EEG spectral analysis prior to anagram solving revealed right-lateralized hemispheric asymmetry predicting subsequent insight problem-solving (Kounios et al., 2008).finding0.715
Evidence that pre-insight neural states (resting EEG) predict insight; supports role of reflection/mind wandering