Pre-somitic mesoderm cells do not oscillate independently but resume oscillating when cultured collectively (Webb et al. 2016)

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• Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.748
  Highlights the non-genetic control of large-scale anatomy.
• Cells hetero-grafted from tissue in one phase of the segmentation clock into a different phase synchronize to the host phase (Horikawa et al. 2006)finding0.747
  Demonstrates that the clock phase is collectively determined; individual cells entrain to the local collective rhythm.
• If different organizations of nervous tissue can achieve the same functions, the possibility that cognitive capacities, including sentience, can be achieved by other tissues should be considered.claim0.743
  Conditional claim urging consideration of non-neural tissues for cognition.
• What mechanisms allow coordination of cell activity toward one consistent morphology?question0.742
  Foundational question driving investigation into how homeostatic capabilities of cells scale to collective setpoints.
• In embryological development, chemistry and cell migrations are mechanisms that do the work but are simply not the principal thing going on — the fifteen properties and their unfolding are.claim0.735
  Alexander's interpretive priority claim distinguishing mechanistic substrate from the morphogenetic principle at work
• DAS overcomes the localist limitation of prior causal abstraction by allowing individual neurons to play multiple roles via non-standard basesclaim0.732
  Central claim motivating DAS over prior methods.
• Bacterial biofilms exhibit bioelectrically-coordinated oscillatory growth patterns, with a negative feedback loop similar to the vertebrate segmentation clock (Liu et al. 2015, Chou et al. 2022)finding0.728
  Shows that collective physiological oscillations in bacterial communities resemble mechanisms in animal development.
• The remarkable ability of neurons to unify toward a centralized self is an evolutionary pivot of far earlier cell communication strategies that first solved problems in navigating anatomical morphospace.hypothesis0.727
  Proposes an evolutionary trajectory linking morphogenesis to neural cognition.