finding
active
finding:mammalian-embryos-overcome-drastic-perturbations-such-as-amputation-and-early-embryo-splitting-results-in-normal-monozygotic-twinsMammalian embryos overcome drastic perturbations such as amputation, and early embryo splitting results in normal monozygotic twins.
Demonstrates mammalian regulative capacity and robust self-organization.
Source paper
extracted_from(2023) · Watson, Richard · Levin, Michael
Neighborhood — ranked by edge-count
Claims (1)
claim
- Rejects reductionist genetic determinism in morphogenesis.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Temporary introduction of breaks in the embryonic blastoderm results in twins, triplets, etc. (Lutz 1949)finding0.798Demonstrates that the blastoderm is a dynamical excitable medium where multiple coherent embryos can self-organize, not fixed by genetics.
- Stress-sharing embryos achieve perfect sequential target patterns; non-sharing limited to <1% improvement.finding0.791Stress-sharing embryos formed each sequential target with stress reducing to zero; non-sharing achieved only tiny improvements.
- Evidence of morphogenetic problem-solving and anatomical homeostasis across serious perturbations; demonstrates collective intelligence in development.
- Shows stress sharing allows perfect formation of part-by-part target patterns.
- Waves of ATP mediate morphogenetic information sharing and teratogen resistance among groups of embryos.finding0.771Tung et al. 2024 finding on cross-embryo morphogenetic assistance (CEMA).
- Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.hypothesis0.761Prior hypothesis tested in the paper; from Levin 2022.
- Tadpoles with scrambled craniofacial organ positions (Picasso tadpoles) develop into largely normal frogs.finding0.756When eyes, nostrils, and jaws were mispositioned, they moved via novel trajectories and stopped upon reaching correct frog face positions, demonstrating anatomical homeostasis.