shorter genes less likely to be damaged at meiosis crossover

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• Mammalian embryos overcome drastic perturbations such as amputation, and early embryo splitting results in normal monozygotic twins.finding0.749
  Demonstrates mammalian regulative capacity and robust self-organization.
• How can we, from the point of view of statistical physics, reconcile the facts that the gene structure seems to involve only a comparatively small number of atoms and nevertheless displays a most regular and lawful activity with a durability that borders upon the miraculous?question0.740
  The specific puzzle about the stability of the genetic material.
• If mutations are isomeric jumps between states with different energy levels separated by a high barrier, then the forward and reverse mutation rates should differ, with the transition from higher to lower energy occurring more frequently.hypothesis0.738
  Hypothesis on the directionality of mutation rates.
• Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.730
  Highlights the non-genetic control of large-scale anatomy.
• MCA creates a more tractable search space by smoothing the fitness landscape, mitigating the inverse problem and enabling survival of mutations that would otherwise be deleterious.claim0.729
  Subclaim.
• If temperature increases, then the mutability of stable wild-type genes should increase more than that of already less stable mutant genes.hypothesis0.729
  Schrödinger's testable hypothesis linking thermal energy to mutation rates.
• Disruptions in cells' ability to join into a cohesive information-processing network via oncogenes and other factors correlate with cancer developmentfinding0.725
  Empirical support for the cancer-as-cognitive-defect / cognitive light cone shrinkage hypothesis
• MCA generates cryptic variance: many mutations neutralized by developmental regulation persist as a hidden diversity pool exploitable in future environments.claim0.722
  Subclaim.