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question:why-do-animals-with-highest-morphogenetic-plasticity-andWhy Do Animals With Highest Morphogenetic Plasticity And
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cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Core open problem: asks how cellular competency affords evolutionary speed and robustness despite the ruggedness of the genotype-phenotype mapping.
- How do organisms achieve robustness and plasticity simultaneously in novel circumstances?question0.763Core question motivating bioengineering studies: how can biological systems adapt to unexpected perturbations while maintaining coherence?
- Robustness in morphogenesis is achieved through plasticity and multiscale problem-solving, not hardwired repeatability.hypothesis0.762Developmental robustness across perturbations arises from the cellular competency to reach the same goal by different means, not from fixed local rules; higher-order robustness.
- Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.hypothesis0.748Prior hypothesis tested in the paper; from Levin 2022.
- Multi-scale competency enables organisms to tolerate mutations and speed up evolutionary search.
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- aboutblank_kbWhy do animals with highest morphogenetic plasticity and regenerative capacity (e.g., planaria) show greatest cancer resistance despite having high proportions of stem cells?questions/why-do-animals-with-highest-morphogenetic-plasticity-and.md0.858