hypothesis
active
prediction:robustness-in-morphogenesis-is-achieved-through-plasticity-and-multiscale-problem-solving-not-hardwired-repeatabilityRobustness in morphogenesis is achieved through plasticity and multiscale problem-solving, not hardwired repeatability.
Developmental robustness across perturbations arises from the cellular competency to reach the same goal by different means, not from fixed local rules; higher-order robustness.
Source paper
extracted_from(2023) · Levin, Michael
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Concepts (1)
concept
- The ability of biological structures to adjust to perturbations (injury, internal modifications) and still accomplish adaptive tasks across multiple problem spaces.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Morphogenesis is trainable via reinforcement learning for specific morphological outcomes.hypothesis0.854If cells form a collective intelligence, they should be trainable by rewards/punishments.
- Levin's main interpretive reframing: rejects purely emergentist/mechanistic views of development in favor of treating morphogenesis as cybernetic, goal-directed problem-solving by cellular swarms.
- How do organisms achieve robustness and plasticity simultaneously in novel circumstances?question0.833Core question motivating bioengineering studies: how can biological systems adapt to unexpected perturbations while maintaining coherence?
- Suggests training tissues as an alternative to micromanaging molecular pathways.
- Proposes a biomedical strategy of controlling growth by exploiting the learning capacity of cellular collectives.
- Key property of morphogenetic process: it produces both unity and diversity simultaneously.
- Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.hypothesis0.819Prior hypothesis tested in the paper; from Levin 2022.
Cross-corpus bridges (9)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbWhat is the relationship between cellular plasticity and robustness to cancer, aging, and injury?questions/what-is-the-relationship-between-cellular-plasticity-and.md0.875
- aboutblank_kbWhat are the limits of regulative development and morphogenetic robustness in the face of different perturbations?questions/what-are-the-limits-of-regulative-development-and.md0.842
- aboutblank_kbWhat mechanisms allow biology to exhibit robustness and plasticity simultaneously, enabling adaptive, coherent organisms in novel circumstances?questions/what-mechanisms-allow-biology-to-exhibit-robustness-and.md0.841
- aboutblank_kbWhat are the features of morphogenesis that enable evolution to search difficult phenotype space efficiently despite pleiotropy, degeneracy, and redundancy?questions/what-are-the-features-of-morphogenesis-that-enable.md0.836
- aboutblank_kbWhat is the relationship between the genome and anatomy, and what mechanisms allow biology to exhibit robustness and plasticity simultaneously?questions/what-is-the-relationship-between-the-genome-and.md0.834
- aboutblank_kbWhat are the failure modes and optimal intervention strategies for morphogenesis?questions/what-are-the-failure-modes-and-optimal-intervention.md0.812
- aboutblank_kbCan morphogenetic setpoints be rewritten without rewiring the genome (in wild-type genomes)?questions/can-morphogenetic-setpoints-be-rewritten-without-rewiring-the.md0.803
- aboutblank_kbHow do organisms adaptively correct developmental perturbations and restore correct morphology?questions/how-do-organisms-adaptively-correct-developmental-perturbations-and.md0.800
- aboutblank_kbWhy do animals with highest morphogenetic plasticity and regenerative capacity (e.g., planaria) show greatest cancer resistance despite having high proportions of stem cells?questions/why-do-animals-with-highest-morphogenetic-plasticity-and.md0.791