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question:how-do-organisms-achieve-robustness-and-plasticity-simultaneously-in-novel-circumstancesHow do organisms achieve robustness and plasticity simultaneously in novel circumstances?
Core question motivating bioengineering studies: how can biological systems adapt to unexpected perturbations while maintaining coherence?
Source paper
extracted_from(2023) · Clawson, Wesley P. · Levin, Michael
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Claims (1)
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- Authors' central interpretive assertion: genome specifies cell-level components but outcome is product of dynamics not easily predicted from genetic sequence.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Robustness in morphogenesis is achieved through plasticity and multiscale problem-solving, not hardwired repeatability.hypothesis0.833Developmental robustness across perturbations arises from the cellular competency to reach the same goal by different means, not from fixed local rules; higher-order robustness.
- Driving question for the research program.
- Central claim linking life's properties to the inherent competencies of its material substrate.
- Multi-scale competency enables organisms to tolerate mutations and speed up evolutionary search.
- Shows plasticity as solution to HFHF in minimal models with homogeneous genotypes
Cross-corpus bridges (4)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbWhat mechanisms allow biology to exhibit robustness and plasticity simultaneously, enabling adaptive, coherent organisms in novel circumstances?questions/what-mechanisms-allow-biology-to-exhibit-robustness-and.md0.860
- aboutblank_kbWhat is the relationship between cellular plasticity and robustness to cancer, aging, and injury?questions/what-is-the-relationship-between-cellular-plasticity-and.md0.810
- aboutblank_kbHow do organisms adaptively correct developmental perturbations and restore correct morphology?questions/how-do-organisms-adaptively-correct-developmental-perturbations-and.md0.804
- aboutblank_kbPlasticity Of Lifeconcepts/cognitive/plasticity-of-life.md0.798