Neurons achieve remarkable centralization through evolutionary reuse of earlier cell communication strategies for anatomical problem-solving

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

• The remarkable ability of neurons to unify toward a centralized self is an evolutionary pivot of far earlier cell communication strategies that first solved problems in navigating anatomical morphospace.hypothesis0.886
  Proposes an evolutionary trajectory linking morphogenesis to neural cognition.
• Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.781
  Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
• Polysemantic neurons are a major challenge for the circuits agenda, because N meanings in one neuron times M in another creates NxM effective connections that cannot be considered individually.claim0.774
  Precise characterization of why polysemanticity poses a combinatorial obstacle to circuit analysis
• Neural bioelectric networks achieve a critical separation of hardware and software: the same molecular substrate can instantiate different informational content based on history, enabling minds to arise from matter.claim0.767
  Foundational for understanding how physiology becomes meaning; decoupling of material state from information content is prerequisite for emergence of cognitive Self.
• Cells and cellular networks have problem-solving capacities that allow them to navigate entirely novel stressors (e.g., barium) without prior selection, implying a general competency beyond hardwired responses.claim0.766
  Derived from the planarian barium adaptation finding.
• Learning neural networks can enable 'chunking' and rescale problem-solving to higher organizational levels, a mechanism intrinsic to transitions in individuality.hypothesis0.766
• Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.765
  Highlights the non-genetic control of large-scale anatomy.
• Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.claim0.764