Mice with mutated semaphorin proteins still produce correct thalamocortical connectivity via a novel path.

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• Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.766
  Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
• Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.758
  Highlights the non-genetic control of large-scale anatomy.
• The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.757
  Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
• Most of Crump et al.'s other criteria are met by non-neural morphogenetic agents via a simple pivot of terms to 'electrically active cell'.claim0.755
  Generalization of the criteria beyond neurons.
• Ion channel-modified cells recruit neighbors to complete eye organogenesisfinding0.754
  Ectopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.
• Cancerous growth can be induced by disruption of electrical coordination signals and reversed by re-establishing them, without genetic changes (Levin 2021a)finding0.751
  Empirical finding in developmental biology that supports organismic individuality independent of genetics
• Non-neural morphogenetic agents satisfy most sentience criteria via electrically active cells rather than neuronsfinding0.748
  Empirical basis for expanding sentience frameworks; shows Crump criteria adaptable beyond traditional neurocentric definitions.
• Cancer can be normalized by reconnecting cells to the electrical network that harnesses them toward adaptive tissue homeostasis.claim0.748
  Proposes a non-toxic cancer treatment strategy.