How Can Development Achieve Correct Morphology Despite Physical

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• What mechanisms allow coordination of cell activity toward one consistent morphology?question0.759
  Foundational question driving investigation into how homeostatic capabilities of cells scale to collective setpoints.
• Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.758
  Highlights the non-genetic control of large-scale anatomy.
• How Do Biological Systems Maintain Anatomically Correct Formquestion0.757
• What Is The Nature Of The Target Morphologyquestion0.753
• All that is required is that this mechanical procedure is sensitive to the whole and is influenced by and guided by the structure of the whole. That is the secret of morphological emergence in natural phenomena.quote0.751
  Load-bearing statement asserting that sensitivity to the whole is the essential requirement for generating novel living structure.
• How cells build specific head shapes or how they know when to stop mitosis and morphogenesis when the correct head shape has been achieved.question0.746
  Identifies the gap in understanding the setpoints and stop signals in anatomical homeostasis.
• What features of morphogenesis enable evolution to search a difficult space with pleiotropy, degeneracy, and redundancy so rapidly and effectively?question0.743
  Core open problem: asks how cellular competency affords evolutionary speed and robustness despite the ruggedness of the genotype-phenotype mapping.
• Can Evolution Exploit Physiological And Morphogenetic Plasticity Toquestion0.739