Migraines and cluster headaches are inappropriate VSMC latches.

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• VSMCs are the brain's compression/prediction infrastructure — where top-down predictive models are physically stored.claim0.736
  Central thesis linking VSMCs to predictive coding.
• VSMC latchesconcept0.720
  Persistent vascular contractions via latch-bridge, proposed to freeze local circuits, sum of which accounts for majority of bodily suffering.
• Sum total of all latches likely accounts for the majority of bodily suffering.claim0.718
  Practical implication of latch-bridge mechanism.
• Smooth muscle tension (especially latched) is involved in a wide range of health problems.claim0.714
  Broad health implication of the theory.
• Latched Hyperprior Hypothesis (LHH): If a vascular contraction is held long enough, it engages the latch-bridge mechanism, durably freezing the nearby circuit and creating a durable commitment to a specific hyperprior isolated from global updating, unlocking only when the corresponding prediction is resolved.hypothesis0.712
  Third core hypothesis, explaining how latched VSMCs instantiate hyperpriors.
• Vascular Clamp Hypothesis (VCH): Vascular contractions freeze local neural patterns and plasticity for the duration of contraction, with specific constrictions encoding specific predictions, functioning as medium-term memory.hypothesis0.705
  Second core hypothesis, linking VSMC contraction to active inference predictions and memory.
• Cells should leak molecules such as HSP90 extracellularly as a stress sharing mechanism.claim0.703
  Prediction for in-vivo biology from the model.
• Vascular Smooth Muscle Cells (VSMCs)concept0.702
  Proposed as the brain's compression/prediction infrastructure where tanha physically manifests; central mechanism in vasocomputation theory.