community
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leiden_hybrid_concepts
label: sonnet
community:leiden_hybrid_concepts-run2-c53Neural crest collective identity plasticity
Grafted neural crest collectives maintain Hox identity while isolated cells adopt host neighbors' expression.
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Bridges (2)
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Findings (3)
- Grafted neural crest cell collectives maintain original Hox gene expression, while individual cells adopt neighbors' expression (Trainor and Krumlauf 2000)Collectives have increased positional memory and resist environmental induction, demonstrating expanded perceptual field in time dimension.
- Individual neural crest or rhombomere cells lose memory of past inductive cues and adopt neighbors' expression; grafted collectives maintain original identity (Trainor and Krumlauf 2000)Collectives have extended temporal perceptual fields, maintaining positional memory that single cells lose.
- Mouse neural crest cells grafted into chicken embryos successfully form teeth (Mitsiadis et al. 2003)Neural crest collective navigates a foreign embryonic environment to achieve its morphogenetic goal.
Claims (1)
- The neural crest acts as an intelligently migrating collective that can alter individual cell behavior to achieve target morphology.Specific claim illustrating collective intelligence in a well-studied embryonic system.