Analgesia preference can be studied and demonstrated in non-neural morphogenetic agents

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• Non-neural morphogenetic agents satisfy most sentience criteria via electrically active cells rather than neuronsfinding0.815
  Empirical basis for expanding sentience frameworks; shows Crump criteria adaptable beyond traditional neurocentric definitions.
• Analgesia Preferenceconcept0.812
• non-neural morphogenetic agentsconcept0.792
  Agents that exhibit cognition-like behavior without neurons, meeting sentience criteria via electrically active cells.
• Most of Crump et al.'s other criteria are met by non-neural morphogenetic agents via a simple pivot of terms to 'electrically active cell'.claim0.777
  Generalization of the criteria beyond neurons.
• Introspective agents generally outperform standard no-pain baseline agents across environments and reward categoriesclaim0.771
  Central empirical claim of the paper supported by statistical tests
• Cybernetic Perspectives On Morphogenesisframework0.758
• Placebo Analgesia Paradigmmethod0.751
  Experimental paradigm holding sensory input constant while manipulating expectations; provides key evidence
• Morphogenetic tissues can be trained via reinforcement learning for specific anatomical outcomes, bypassing the complexity of genomic editing.claim0.748
  Proposes a biomedical strategy of controlling growth by exploiting the learning capacity of cellular collectives.