Isomeric molecules are equally stable despite identical energy levels because transition requires passage through higher-energy intermediate configurations.

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• If mutations are isomeric jumps between states with different energy levels separated by a high barrier, then the forward and reverse mutation rates should differ, with the transition from higher to lower energy occurring more frequently.hypothesis0.814
  Hypothesis on the directionality of mutation rates.
• If the gene is a large molecule with discrete quantum states and high energy barriers between isomeric configurations, then it will exhibit long-term stability and rare spontaneous mutations.hypothesis0.800
  The core predictive hypothesis derived from Delbrück's model.
• Newtonian mechanics augmented by statistical mechanics cannot explain chemical bond stability or genetic persistence; quantum mechanics is necessary.claim0.791
• Multi-stable mechanical systems with energy barriers (ratchets) provide a physical model for how genetic states persist and discretely change.hypothesis0.772
• On a growing crystal, incoming molecules preferentially attach where binding energy is greatest, causing plane faces to perpetuate themselves and wholeness to be preserved in crystal growth.finding0.772
  Physical chemistry finding illustrating a purely local mechanism that nonetheless produces global structure preservation
• Aperiodic structure of genetic molecules enables exponential diversity of encodable information compared to periodic crystals.claim0.764
  Schrödinger argues that non-repeating molecular structure (aperiodic solid) allows information density far exceeding periodic/crystalline alternatives.
• The relationship of the new volume to the existing structure is almost like a molecular lock-and-key relationship.claim0.764
  The fit is highly complex, very specific, and definite, analogous to protein-ligand binding.
• Quantum theory reveals discreteness of atomic/molecular states with energy levels and quantized transitions.finding0.758
  Foundational quantum-mechanical fact that Schrödinger leverages to explain why molecular configurations are stable against small thermal perturbations.