concept
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concept:disruption-profiledisruption profile
The output explanation format of Evee, quantifying how a variant disrupts different genomic features.
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Papers (1)
paper
Methods (1)
method
- Evee variant effect prediction methodimplementsThe method that predicts and explains variant pathogenicity using Evo 2, producing disruption profiles.
Concepts (1)
concept
- mechanistic explanationassociated_withExplanations derived from model internals that describe the biological mechanism of variant effect.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Mechanistic explanation outputs from EVEE showing how variants affect gene function, scored 3.8/5 for explanation quality.
- Claim supported by the 3.8 vs 2.8 human rating finding.
- A multi-dimensional characterization of a model's misaligned behaviors across different behavioral categories
- A parameterized rubric counting deceptive actions over a grid of parameters to quantify RL agent deception
- Disruption profiles scored 3.8/5 for explanation quality vs 2.8/5 for metadata-only baselinesfinding0.730EVEE's mechanistic explanations significantly outperform simple metadata-based predictions in human evaluation.
- The property that living structures contain intense contrast—far more than one imagines helpful; true opposites which annihilate each other when superimposed, creating differentiation that gives birth to something; contrast unifies rather than separates when used correctly
- When non-orthogonal features cause logistic regression to identify a suboptimal probe direction
- Classical RL algorithm adapted by the paper with modifications including clipped-surrogate losses and length-normalized advantages for agentic training.