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leiden_hybrid_concepts
label: haiku
community:leiden_hybrid_concepts-run4-c2-c8Bioelectric codes in collective morphogenesis
Cellular networks use bioelectric signaling for goal-directed anatomical patterning, demonstrated via xenopus eye-field manipulation and morphological problem-solving by cell collectives.
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Bridges (4)
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Claims (3)
- Cellular collectives navigate morphological problem space via error minimization
- In axial patterning, collective decision-making enables large numbers of cells in a compartment to agree on an organ-scale anatomical fate despite stochastic influences upstream.Generalization of the all-or-none and cryptic planaria phenomena to axis formation.
- Morphogenesis by cell groups is a natural example of a collective intelligence problem.Reframes developmental biology as a cognitive science.
Findings (2)
- Anatomical homeostasis is a goal-seeking capacity of collective intelligence of cellular swarms; bioelectric networks controlled morphogenesis before controlling behavior.Demonstrates that intelligence and goal-directedness operate in problem spaces beyond 3D behavioral space; supports basal cognition framework.
- Induced large eye-field fragments into multiple normal-sized eyes instead of one giant eye (Pai et al. 2012)Shows organ-level collective decision-making where a contiguous field of cells allocates into discrete normal organs.