concept
active
concept:bioelectric-control-layer

Bioelectric Control Layer

A key interface exploited by evolution to accomplish morphogenesis; cells perform computations via ion channel voltage dynamics; enables integration of information across scales toward large-scale morphogenetic goals.

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Methods (1)

method
  • Ion Channels and Pumps
    implements
    Cellular machinery controlling resting potential and voltage dynamics; manipulable via drugs or optogenetics to modulate morphogenetic outcomes.

Concepts (2)

concept
  • Morphogenesis
    implements
    Process by which cellular collectives generate large-scale structure and form; presented as a collective intelligence problem.
  • Gap Junctions
    implements
    Cellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.

Findings (2)

finding
  • Ectopic Eye Formation via Bioelectric Signaling
    supports
    Misexpression of potassium channels in frog tadpole gut or tail induces formation of complete, functional eyes in ectopic locations; demonstrates that morphogenetic modules can be triggered by high-level bioelectric signals without specifying molecular details.
  • Bioelectric Head Patterning in Planaria
    supports
    Bioelectric gradients regionalize gene expression to determine head structure in planaria; system can be hijacked by microbes to control host head number and morphology.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.