For DNA database search, it is usually more efficient to run many sequential searches in parallel than to parallelize individual searches.

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

• For a given task, the number of all sequences which work is tiny by comparison with the huge number of all possible sequences; less than a trillionth of all 6 × 10^23 possible sequences actually work well enough.claim0.771
  A combinatorial argument that good sequences are astronomically rare, emphasizing the difficulty of discovery.
• The multiscale competency architecture (MCA) speeds evolutionary search by providing generalization, reliability, tractable search space, cryptic variation, and functional intermediates.claim0.768
  Main functional claim about MCA.
• DAS finds better alignments than brute-force search by using gradient descent rather than exhaustive discrete searchclaim0.754
  Second central claim of the paper.
• MCA creates a more tractable search space by smoothing the fitness landscape, mitigating the inverse problem and enabling survival of mutations that would otherwise be deleterious.claim0.751
  Subclaim.
• Simple experiments with an in-memory Sqlite database suggest dynamic binding operations take several orders of magnitude longer than a dedicated language runtime support library.finding0.742
  Empirical observation that a relational engine is too slow for associative lookup, motivating specialized implementation.
• In parallel programming, asynchronous communication is far more common than synchronous.claim0.739
  Basis for preferring Linda's out (asynchronous) to remote procedure calls.
• DNA Sequence Comparison Problemconcept0.736
• A cleaning process goes on in parallel with differentiating, keeping the structure spare and simple so that there is always room for more relationships; this is the only way profound, well-adapted structure can be built.claim0.733
  Describes the dual process of complexity buildup and simplification, leading to the beauty of primitive art and nature.