Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs

{
  "doi": "10.1039/c5ib00221d",
  "year": 2015,
  "title": "Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs",
  "authors": [
    "Giovanni Pezzulo",
    "Michael Levin"
  ],
  "abstract": "A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configurations, rules, and patterns) and coordinate their activity towards proximal and distant goals. In this Perspective, we propose that programming large-scale morphogenesis requires exploiting the information processing by which cellular structures work toward specific shapes. In non-neural cells, as in the brain, bioelectric signaling implements information processing, decision-making, and memory in regulating pattern and its remodeling. Thus, approaches used in computational neuroscience to understand goal-seeking neural systems offer a toolbox of techniques to model and control regenerative pattern formation. Here, we review recent data on developmental bioelectricity as a regulator of patterning, and propose that target morphology could be encoded within tissues as a kind of memory, using the same molecular mechanisms and algorithms so successfully exploited by the brain. We highlight the next steps of an unconventional research program, which may allow top-down control of growth and form for numerous applications in regenerative medicine and synthetic bioengineering.",
  "arxiv_id": null,
  "pdf_status": "not-available",
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  "openalex_match_title": "Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs",
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    "W75393200",
    "W134924349",
    "W182941180",
    "W1018855955",
    "W1418557530",
    "W1505640478",
    "W1585717125",
    "W1591713425",
    "W1594493864",
    "W1595494026",
    "W1747101780",
    "W1774371590",
    "W1821682412",
    "W1846801464",
    "W1848087237",
    "W1927644290",
    "W1953215483",
    "W1953797643",
    "W1965456488",
    "W1967470318",
    "W1967965852",
    "W1968459684",
    "W1968729159",
    "W1969002109",
    "W1970694334",
    "W1970762654",
    "W1971368484",
    "W1971614299",
    "W1971803560",
    "W1972358599",
    "W1974257328",
    "W1978336129",
    "W1978520237",
    "W1978824070",
    "W1978957620",
    "W1979732124",
    "W1980006923",
    "W1980920464",
    "W1981986053",
    "W1982334864",
    "W1984407360",
    "W1985024978",
    "W1985607929",
    "W1989859381",
    "W1989874421",
    "W1991789313",
    "W1991974088",
    "W1992168403",
    "W1992683617",
    "W1996033696",
    "W1996361194",
    "W1996874802",
    "W1996994627",
    "W1997451298",
    "W1998567810",
    "W1999027472",
    "W1999653836",
    "W1999892396",
    "W2001389812",
    "W2001685400",
    "W2001696678",
    "W2002423417",
    "W2003107064",
    "W2005533829",
    "W2005576705",
    "W2006779040",
    "W2006832086",
    "W2008123493",
    "W2008812368",
    "W2009218770",
    "W2010142066",
    "W2010943600",
    "W2011589116",
    "W2014173127",
    "W2017098687",
    "W2017532423",
    "W2018043075",
    "W2019711191",
    "W2022003983",
    "W2022305914",
    "W2022965779",
    "W2023722569",
    "W2026127316",
    "W2027181861",
    "W2029062076",
    "W2029401690",
    "W2029966292",
    "W2032295980",
    "W2032803618",
    "W2034406403",
    "W2036145275",
    "W2036173715",
    "W2036735052",
    "W2038836884",
    "W2039435553",
    "W2039888453",
    "W2040895383",
    "W2043567981",
    "W2044341429",
    "W2044606159",
    "W2045396155",
    "W2046215628",
    "W2048644480",
    "W2048672935",
    "W2048843035",
    "W2049944666",
    "W2050703693",
    "W2051117666",
    "W2051300753",
    "W2051823419",
    "W2052568503",
    "W2053120786",
    "W2053155900",
    "W2053232789",
    "W2053487364",
    "W2055256257",
    "W2055789905",
    "W2057498423",
    "W2058918256",
    "W2059320470",
    "W2059530663",
    "W2060177656",
    "W2062978232",
    "W2063224437",
    "W2064572662",
    "W2065693451",
    "W2067740028",
    "W2068849765",
    "W2070142436",
    "W2071392077",
    "W2071519874",
    "W2073728900",
    "W2073820635",
    "W2074025698",
    "W2074374359",
    "W2076458597",
    "W2076499916",
    "W2077106910",
    "W2077292538",
    "W2078355959",
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    "W2084834461",
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    "W2099365483",
    "W2100676539",
    "W2100801711",
    "W2100967971",
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    "W2101692583",
    "W2101959828",
    "W2102007378",
    "W2102126793",
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